organs and systems if necessary, in our case within spectrum band. The aim of the present study was the identification of risk patients at the time of ICU arrival by bedside assessment of hemodynamic function and cardiac biomarkers in septic shock. We hypothesized that once a person is being identified as a critically ill patient with a greater risk of death, it would allow the medical team to initiate a more aggressive and a more effective treatment within the first minutes of the primary care. The goal would be to achieve a quicker decision process during intensive medical care, e.g. the earlier administration of fluids, antibiotic or vasoactive agents, which can be done in any medical environment (emergency room, ICU or ward).

The aim of the present study was the identification of risk patients at the time of ICU arrival by bedside assessment of hemodynamic function and cardiac biomarkers in septic shock. We hypothesized that once a person is being identified as a critically ill patient with a greater risk of death, it would allow the medical team to initiate a more aggressive and a more effective treatment within the first minutes of the primary care. The goal would be to achieve a quicker decision process during intensive medical care, e.g. the earlier administration of fluids, antibiotic or vasoactive agents, which can be done in any medical environment (emergency room, ICU or ward).. Previous reports indicate that male gender is present in 60—66% of cases and children in the first and second year of life are predominantly affected [45-47]. Our data regarding the incidence where can i buy provigil in south africa gender, and age of patients with foreign body aspiration were consistent with the literature. Aspirated foreign bodies can be classified into two categories, organic and inorganic. Most of the aspirated foreign bodies are organic materials, such as nuts and seeds in children, and food and bones in adults. The most common type of inorganic aspirated substances in children are beads, coins, pins, small parts of varies toys, and small parts of school equipment such as pen caps [48]. As we listed the different type of foreign bodies in Asian countries such as India, [22] China, [36] and Turkey [23] the most common were organic type include peanut, ground and dried nuts, while in European countries such as Italy [25] and Kosovo [30] the most common were organic type include dried nuts as well as inorganic type in some countries like Spain [33]. The most common at risk age found less than 3 years in most reported paper that was in agreement with our study [22 - 37].. was that...I might have confused you a

was that...I might have confused you a. We studied the LWBS rates by triage class and target wait times required to achieve various LWBS rates..

Anisakiasis is a disease related to infection of Anisakis larvae through consumption of raw seafood. It is particularly popular in Japan but has also been reported in a number of countries. Gastric anisakiasis is caused by gastric mucosal penetration of larvae and can present with a variety of manifestations and endoscopic findings. While epigastric pain is the most frequent complaint, other symptoms including nausea, vomiting, diarrhea, and allergic signs have also been reported.1, 2 EGD could be both diagnostic and therapeutic in gastric anisakiasis patients, by visualizing and removing the larvae. However, penetrating Anisakis larvae are not always immediately seen, as in the present case. Frequent EGD findings include mucosal edema, ulcers, as well as submucosal tumor formation.1, 3. Combination OCs are ineffective after about 3 months of use.

Combination OCs are ineffective after about 3 months of use.. The spectrum of mutations in the BRCA genes varies between populations, with some showing a high frequency of unique mutations [11]. Many such alterations may be recurrent, often being identified in isolated populations as a founder effect [12] and may contribute to differences in cancer risk between populations [13]. Ashkenazi Jewish, Norwegian, Dutch, and Icelandic people have a higher rate of certain genetic alterations in BRCA1 [14]. However, the contribution of mutations in BRCA genes to BC patients in the Moroccan population remains unexplored and few molecular genetic study of BRCA status has been reported [15]. In order to investigate the contribution of germline mutations of BRCA1 to BC in the Moroccan population, we screened 121 BC cases for alterations in all coding exons and splice junctions of BRCA1 gene.

The spectrum of mutations in the BRCA genes varies between populations, with some showing a high frequency of unique mutations [11]. Many such alterations may be recurrent, often being identified in isolated populations as a founder effect [12] and may contribute to differences in cancer risk between populations [13]. Ashkenazi Jewish, Norwegian, Dutch, and Icelandic people have a higher rate of certain genetic alterations in BRCA1 [14]. However, the contribution of mutations in BRCA genes to BC patients in the Moroccan population remains unexplored and few molecular genetic study of BRCA status has been reported [15]. In order to investigate the contribution of germline mutations of BRCA1 to BC in the Moroccan population, we screened 121 BC cases for alterations in all coding exons and splice junctions of BRCA1 gene..

HAART is the only technique to combat against HIV which can only. any organism of choice, DNA sequences can be modulated or edited. Association of NS1 with chromosomal DNA was detected using chromatin immunoprecipitation. HepG2 cells were transfected with the GFP/NS1 expression vector or GFP vector alone and metabolically labeled with 32P-thymidine triphosphate during the protein expression phase of the experiment. Labeled DNA was detected by autoradiography and proteins were detected by Western blotting. Radioactivity was found in specific bands that perfectly overlapped with bands formed by GFP/NS1 where can i buy provigil in south africa but not GFP, as revealed by Western blotting (Figure 1). The colocalization of the radioactive signal with NS1 shows that DNA is bound to NS1 in the lysate. The harsh denaturing methods used both in the immunoprecipitation and in the preparation of the samples for SDS-PAGE strongly suggest that DNA could not have been present with the NS1 fusion protein unless covalently linked. Treatment of the immunoprecipitate with DNase before SDS-PAGE decreased the radiographic signal by 63%, indicating that the radioactive label is DNA, and not from another source such as phosphorylation of NS1 (Figure 1).. severe symptoms.

severe symptoms.. woman, it is reasonable to monitor TSH over 3—6 months to. Serum sES levels were measured in 27 pneumonia patients where can i buy provigil in south africa who were enrolled between April 2006 and September 2007. Among these patients, six had ALI or a condition that was clinically comparable to ALI (cALI). All patients who were enrolled were successfully treated and survived.. Elderly people who practice exercises regularly have a better health status and improved functioning; additionally where can i buy provigil in south africa they can present a 35% reduction of hospitalization, as well as 37% decrease of total health costs [29]. In summary, exercise practice can reduce the risk for T2D in adults and elderly, even in the presence of excess of general or central adiposity [3, 11, 14, 15, 22, 26]. Therefore, exercise has been considered a primary prevention, low cost and non-pharmacological strategy that can be used in public health initiatives to prevent diabetes in managed care and community setting [1, 22, 29]. Health professionals should encourage individuals of all ages to maintain an active life-style that can attenuate the negative physiologic changes that accompany advancing age, leading to T2D..

Dr Mandy Deeks, Jean Hailes. A 51 year-old male with CML in chronic phase had been treated with 400 mg imatinib for two and a half years. Although bcr-abl transcripts decreased transiently to less than 1,000 copies in 1 μg RNA extracted from PB cells (3-log reduction = 280 copies in 1 μg cellular RNA; median in our laboratory, n=120) during the imatinib treatment, the transcripts gradually increased to more than 4,000 copies spontaneously thereafter. Imatinib was increased to a dose of 600 mg and continued for 4 months, which caused adverse effects such as worsening of anemia and limb pain with increased CK. Therefore the dose of imatinib was decreased to 400 mg. Thereafter bcr-abl transcripts decreased transiently to 500 copies during the imatinib treatment, which was speculated to be the late effects of imatinib therapy at the dose of 600 mg a day. However, bcr-abl transcripts gradually increased to more than 1,000 copies thereafter. Since the patient was HLA-A*2402+ and informed consent was obtained, modified-type WT1 peptides, which had been identified to possess an anti-tumor immunogenicity [7], were administered subcutaneously at the dose of 1 mg every 2 weeks in combination with 400 mg imatinib. After the second administration of the peptides, WT1 peptide/HLA-A*2402 (WT1/MHC) tetramer+CD8+ T cells began to be detected in PB at a frequency of 7x10-6 in PB-CD8+ T cells. After the fourth administration of WT1 peptides, bcr-abl transcripts decreased to 820 copies with an increase in the frequency of WT1/MHC tetramer+CD8+ T cells in PB. However, bcr-abl transcripts increased to more than 1,000 copies after the eighth administration of WT1 peptides, though the frequencies of WT1/MHC tetramer+CD8+ T cells in PB were maintained at a considerable level. Since there was a report that some anti-tumor CD8+ CTLs lose their cytolytic activity by strong antigenic stimulation [9], the interval of WT1 peptide administration was changed from two weeks to four weeks after the eleventh administration of WT1 peptides. Although bcr-abl transcripts rose up to 2,600 copies after 12th administration of WT1 peptides, thereafter the transcripts tended to decrease and fell to 400 copies after 22nd administration of WT1 peptides. After seven months from the cessation of WT1 peptide vaccination bcr-abl transcripts decreased to the level of a major molecular response (170 copies). Four months thereafter, bcr-abl transcripts achieved to the level below detection by RQ/RT-PCR (complete molecular response) (Fig. 1). WT1/MHC tetramer+CD8+ CTLs are still present in the blood on 14th month post cessation of the peptides. No adverse effects due to WT1 peptide vaccination was observed except for skin induration and redness at the sites of WT1 peptide injection..

viral systemic spreading function. As a result, CP can be deleted to. inshore substrata of tropical and temperate waters where can i buy provigil in south africa with three to four.

Eradication of poliomyelitis seems to be more feasible than ever. During recent years the strategy has reached milestone goals, faced new challenges, and re-configured by itself. In this text we describe the current situation of the polio eradication efforts worldwide and present an analysis of the potential implications and needs regarding vaccination in the coming years.. Results of the subgroup analysis by type of residence after discharge are shown in Table 4. Codes of food texture were lower in the mobility group for both subgroups..

written permission for the study to be conducted at the study site with. Top foods at midlife. analyzed with SDS software (version 2.0.6; Applied Biosystems Inc.,

analyzed with SDS software (version 2.0.6; Applied Biosystems Inc.,. legal consideration matters too but as ethics shall be the source of. antibodies to Salmonella are linked to paramagnetic beads allowing for. − × 100. natural state. During the food

natural state. During the food. Clearly where can i buy provigil in south africa a common finding among above studies is that BRCA-/- pre-cancerous cells are very sensitive to PARP inhibition than wild type cells while cancer cells exhibit different response to PARP inhibition under different conditions [24, 25, 33, 34, 36]. Animal studies showed that BRCA1- and BRCA2-deficient embryos die during embryonic development [37, 44-46]. Adults with BRCA1/2 associated hereditary breast cancer inherit one mutated allele through their germline and later suffer loss of heterozygosity of the wild type allele in order for breast cancer to arise. There must be at least one previous mutation in another gene however, that is permissive, for viability of the cell in the event of a second BRCA mutation. Current data suggest that ATM, CHK2 and p53 may be candidate genes for these permissive mutations as impaired functions of these genes, either at heterozygous or homozygous forms, attenuates apoptosis induced by BRCA1 deficiency and allows mutant embryos survive to adulthood [40, 42]. The extended survival of BRCA deficient cells allows for further genomic alterations leading to the eventual development of cancer.. In NASH group where can i buy provigil in south africa levels of AST, ALT, ET, DAO, NAS, liver index and intestinal permeability were higher while occludin expressions were lower than control and NASH-TFF3 treated groups (p <0.05). Histopathology examination showed pathological damages of liver and ileum were alleviated in NASH-TFF3 treated group. NASH-TFF3 treated group had decreased expression levels of TLR4 and NF-κB and increased expression levels of Muc2 than NASH group. Besides, NASH group showed increased IL-1β and IL-10 levels compared with control group. NASH-TFF3 treated group showed decreased IL-1β level however increased IL-10 level compared with NASH group.. amount of time and effort in the performance of the experiment. After. • Transdermal — patch or gel (avoiding first. Twenty-five patients with type II diabetes mellitus (mean age 52.24 years), 17 patients with secondary Raynaud phenomenon (mean age 47.06 years), non-smokers without pulmonary or heart disease, and 26 healthy matched subjects (mean age 47.50 years) underwent lung diffusion capacity measurements by single-breath method also corrected by alveolar volume (DL,co) in sitting and supine positions.. Liangas G, et al. associated the detrimental effects of laughter with bronchial asthma. (17) Bronchial asthma can be triggered by: allergic reactions, various pharmacological agents, the environment, occupation, infections, exercise and emotions. Laughter is composed of both a physical (exercise) and emotional component. Perhaps, laughter, as a form of exercise and as an emotional response triggers bronchial asthma, and thus a potent stimulus. Specifically, the physical aspect (exercise) of laughter was considered to cause exercise associated bronchial asthma which is prevalent at a later age. (18,19, 20) According to Gayrard P, 52.4% of 143 asthmatics stated their attacks of bronchial asthma were induced by laughing. (18) It was suggested, hyperventilation might be a cause to laughter-associated-asthma, in addition to stimulation of irritant receptors in the airway epithelium. (17) The second mechanism being the prevalent one admixed with the mechanism of hyperventilation seemed to appropriately describe laughter-associated-asthma..

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On Friday, I finished a book. It’s a tragically rare occurrence, these days. Even more unusually, it was a novel—Richard Matheson’s The Beardless Warriors, an autobiographical bildungsroman set among U.S. infantryman fighting the Second World War in Europe.

The main character, Hackermeyer, is one of several “beardless” teenage soldiers in an infantry squad under thirty-something Sergeant Cooley, who becomes, inevitably, a father figure to the “kids” that fight and die under his command. “Hack,” whose own family background is abusive and neglectful, forms a very close bond with Sergeant Cooley, and essentially the novel is about Hack finally coming to understand love and familial belonging against the horrific backdrop of war. It’s a cliché, now, though I don’t really know enough about the genre to say whether that arc was quite so tired when The Beardless Warriors was originally published.

Cliché or no, it works for me, and I did enjoy the book. While reading, I assumed that it was Matheson’s first novel, and that he’d written it shortly after coming back from his own tour in Europe, sometime in the late ’40s. Though that may well be the case, The Beardless Warriors was not actually published until 1960. But, in any case, it reads like a first novel, to me. The prose, pacing, and dialogue are often clunky, though there are undoubtedly some very effective—almost brilliant—moments.

As an example of the former, here’s an especially clumsy paragraph from near the end of the book, during the climatic assault on Saarbach:

Hackermeyer started shooting as Guthrie and Tremont ran around the rubble heap and into the square, picking up impetus as they ran. He noticed that Tremont kept his eyes on Guthrie. The moment Guthrie buckled his knees and fell, Tremont did the same. Guthrie started firing at the building; Tremont lay shivering in the snow.

Here’s how I would edit/rewrite it:

Hack started shooting as Guthrie and Tremont bolted into the square, picking up speed as they ran. Tremont followed Guthrie’s lead, falling and covering when he did. But when Guthrie opened fire on the building, Tremont just lay there, shivering in the snow.

Some of these edits could be boiled down to stylistic differences, but I don’t think there’s any denying that some of Matheson’s original prose is just sloppy. He favors a “brutalistic,” vaguely Hemingwayesque style, but that doesn’t justify awkward, inefficient, wordy phrases like “He noticed Tremont kept his eyes on Guthrie.” The entire novel is told from Hackermeyer’s POV, after all, so “He noticed” is pretty much always going to be unnecessary verbiage. It’s no more necessary to mention Hack’s “noticing” Tremont keeping his eyes on Guthrie than it is later, in the same paragraph, to say “he noticed Guthrie started firing at the building” or, “he noticed that Tremont lay shivering in the snow.”

Here’s another paragraph, from the same scene, that could’ve benefited from some attentive editing:

Shells exploded all around. They rocked the earth and detonated Schu mines, jetted murky clouds of mud into the snow-filled air. Razor-edged cleavers of shrapnel shot in all directions, walls of concussion slammed against them. Hackermeyer trembled, helpless, cleaving to the mud as if gravity had lost its hold and he resisted being sucked into the sky. Thought was gone again. He was a mindless clump of flesh and bone, welded to the floundering earth.

My version:

Shells exploded all around. They rocked the earth, detonating buried landmines and blasting jets of mud into the freezing air. Razor-edged shrapnel cleavers shrieked in all directions. Walls of concussion slammed against them. Hack trembled, helpless, clinging to the ground as if the sky were an abyss into which he might fall. Thought and mind were gone, again, and he was just a clump of quivering flesh, welded to the floundering earth.

Again, stylistic choices. But consider, particularly, Matheson’s evocative but awkwardly-phrases simile: “Hackermeyer trembled, helpless, cleaving to the mud as if gravity had lost its hold and he resisted being sucked into the sky.” First, the homonym verb “cleaving” coming right on the heels of the noun “cleaver” (just used to describe the flying shrapnel), is repetitious, as is the reappearance of “mud,” which is both the object to which Hackermeyer clings and the substance “jetted” into the air two sentences before. Then there’s the mess at the end: “as if gravity had lost its hold and he resisted being sucked into the sky.” It is a nice image, but there has to be a more eloquent way of expressing it.

I also marked some passages that I liked. This exchange between Hackermeyer and “sad clown” squad-mate Guthrie actually works pretty well, for me, unlike much of Guthrie’s humor, which tends to fall flat (though very often, in fairness, it is supposed to):

“You’ve heard about our good Sergeant Wadley>” said Guthrie.
“Was he killed?”
“No such luck,” said Guthrie. “He ran off.”
“When?”
“Yesterday during Nazi artillery practice.”
Hackermeyer frowned. “How come?”
“He was alarmed,” said Guthrie. “Threw down his gear and scooted off like Chicken Little. Claimed the sky was falling down.”

He was alarmed. Comic understatement for the win. Here’s another good Guthrie moment:

Machine-gun fire started ripping close above and Hackermeyer scrabbled for the nearest shell hole. MacFarland followed.
“What the hell is happening?” raged MacFarland.
Hackermeyer started to reply when a body came crashing down on top of them.
“Sorry, men!” said Guthrie, scrambling off them. He saluted with his left hand, his face contorted, smeared with mud. “It is a good war, men, a true war!”
“Go screw yourself!” MacFarland shouted at him.
“It is an ill-advised project, father!” Guthrie shouted back.

During the assault on Saarbach, Hackermeyer and his squad fight their way past a statue of Christ on the Cross that had earlier been identified to them, during operational planning, as a tactical landmark. In fact, Matheson does not belabor the symbol of Christ crucified amongst the desolation and horror of war, which is all for the best, as far as I am concerned, because it is not exactly subtle. The image only stuck in my mind because it reminded me of an essentially identical scene in Samuel Fuller’s 1980 movie The Big Red One, which is also an autobiographical story of infantry combat in WWII Europe. In Fuller’s movie, the crucifixion image is rather overplayed, I think, but at least visually it is quite striking: The wood of Christ’s face is bleached, weathered, and cracked, and is covered with crawling red ants. Matheson also explicitly mentions the “weather-worn face and body on the cross,” and I was led to wonder if A) the similar imagery is purely coincidental B) the crucifix in The Big Red One was borrowed, consciously or not, from Matheson’s chronologically earler work, or C) both Matheson and Fuller independently encountered a weatherbeaten statue of Christ crucified while they were actually on the ground, in combat, in Europe, and the experience made such an impression on each of them that it later, independently, found its way into each man’s art. Case (C), of course, is the most interesting, and if I had time for idle scholarship I think it’d be fun to try to run down an answer. Did they both see the same statue? Is it still standing?

Anyway. I’m going on to read more Matheson, I think. The same friend who recommended The Beardless Warriors just loaned me her copy of Matheson’s short story collection Duel. Will be interesting to compare.

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Though skeptical, I decided to experiment with adding a facial exercise routine to my regimen back in November, and took a “before” picture (left), so I could compare later on and decide if it was worth keeping up with. The photo on the right was taken 60 calendar days later, having done the exercises five days out of every seven, about ten minutes each morning and evening, during the intervening time.

There’s no doubt my face looks stronger and better defined, but I would not characterize it as “younger.” In fact, I’d say it’s aged me, most noticeably by deepening my “smile lines.”

Of course, Xmas happened between the first picture and the last, and it at least feels like I do 80% of my aging, each year, over the holidays.

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This is the first full print off my buy provigil at walmart FFF 3D printer. A shot glass is the traditional “maiden” print among RepRappers—it’s a quick, simple object and the libation-tightness of the finished print is a pretty good test/demonstration of the printer’s abilities. In fact, the traditional file is buy provigil american express, which I elected to forego in favor of this slightly larger and more impressive shot glass, which is buy provigil online south africa. It is teardrop-shaped in honor of the RepRap project logo. It was printed from red 1.75mm polylactic acid (PLA) filament on the evening of Tuesday, January 17, at a small party my friends and I had to celebrate the event. We each independently verified its Glenfiddich-tightness. The traditional playing of Daft Punk’s Human After All album, during the printing, was also observed. The rhytmic, protomusical whines of the Cartesian robot’s stepper motors are a good complement to most Daft Punk songs.

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In the house next door is a family of four—a married man and woman and their teenage son and daughter. I met the woman shortly after moving in, at the mailbox, and when she heard I worked for MAKE, she started talking about her son, who builds exotically-shaped Rubik’s cube-type twisting puzzles and sells them to enthusiasts around the world. I wrote buy provigil fast shortly thereafter.

A few weeks later, while working outside of a morning, I heard a familiar sound over the fence in their backyard: a light metallic whang, repeating three times, with ten seconds or so between each, and then 30 or 45 before the group of three repeated. I knew the sound, but it took me a minute to reach back into memories of my own adolescence and place it: someone was practicing with throwing knives.

I stuck my head over the fence and said hello. The boy brought over his throwing knives—three of them, handmade from pieces of an old circular sawblade. I still have my own set (though mine were bought, rather than made) from when I was almost exactly the same age, doing almost exactly the same thing.

The boy and I struck up a friendship, and since that time he has rung my doorbell once or twice a week. And each time he brings over something he’s made, to show off. That, and questions: How would I make this? How would I find out about this? Where would I get this?

And the uncanny similarities between him and me, when I was his age, keep piling up.

I’ve taken lately to passing down some of my unfinished projects to him, some of my venerable and treasured junk. Around the beginning of December, I made a gift of two old blades left over when I dismantled a pair of cheap display swords, a few years back, to get at some decorative castings on their handles. He fit one of the blades with a full tang wooden handle and kept for himself. The other he fit with this elaborate guard and hand shield he welded up from steel wire. Then he mounted it on a piece of oak, decorated with his own pyrography, and presented it to me as a Xmas present.

The blade is a bit over two feet long, from pommel to tip, and the display board a bit under that. It’s probably not actually usable, but that is hardly the point. I hung it up on my office wall and intend to display it there, or someplace equally proud, for a very long time.

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I buy provigil israel about my interest in grenade-shaped energy drink buy provigil in thailand as a cultural artifact. I bought the inner two bottles, shown above, in early 2009. Each is displayed next to a promotional photo of the same flavor; to left, “ruby orange,” and to right, “original.” My bottles are dated “best before 05.22.09” and “best before 09.07.09,” respectively.

Part of the Bomba gimmick is the “pin” on the bottle cap, so I never opened the bottles in order to preserve the effect. I displayed them, over the intervening years, with other bottles and knick-knacks in a windowsill. “Ruby orange,” left, has been bleached almost water-white, I presume by sunlight. Since the drink is so far past its expiration date, it is, I suppose, possible that some kind of very slow solution-phase bleaching process is responsible. But evident photobleaching of the inks on the paper labels on the outside of the bottles (as well as notable buy provigil online in canada) strongly suggests that photochemistry is the culprit.

“Ruby orange” lists buy provigil online ireland on the label, whereas the apparently unaffected color of “original” Bomba, to right, lists “artificial color (where to buy provigil in singapore)” in place of the red dye.

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…on the charger for my new Norelco 7310XL. As near as I am able to interpret, it means, “do not cut this cord off.” The charger’s rated output is only 350 mA at 15V DC, which is scarcely hazardous; even if you were to cut the cord with uninsulated metal scissors, while it was plugged into mains power, the worst-case scenario is probably a noticeable tingle. Perhaps a cut, shorted cable could heat up and, eventually, somehow, cause a fire? If it were 1AM on Friday the 13th and you had just broken a mirror while chasing a black cat under a ladder in the process of killing an albatross?

Is it even a hazard warning at all?

I am now, in fact, almost so curious about the label’s purpose as to attempt exactly what it seems to forbid, just to see what happens. My charger will stop working—that much I’m quite sure of. But surely no one capable of operating an electric razor, in the first place, would be surprised at that outcome. What about all the other possible ways I could destroy the charger? If it needs a “do not cut off cord” label, doesn’t it also a need a “do not blast with a shotgun” label? Doesn’t everything else I own? “Hello, Norelco customer service? I vaporized my charger with a thermal lance and it stopped working. What gives? Shouldn’t there be a label or something?”